Downstream Processing Market Highlights Key Development Factors and Upcoming Trends During Forecast to 2022-2030

Ligand Technologies for Purifying COVID-19 Vaccines Reviving Market Growth

The latest advancements in downstream processing include ligand technologies for purifying RNA and COVID-19 vaccines. Companies in the downstream processing market are in many talks such as Navigo Proteins and Repligan, who have developed an affinity ligand targeting the SARS-CoV-2 spike protein for the purification of COVID-19 vaccines. They are focusing on the development and validation of a related affinity chromatography resin, which improves yield during the manufacturing of COVID-19 vaccines.

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In order to keep economies running, companies in the downstream processing market are developing platform-based purification solutions. They are taking efforts to innovate in affinity chromatography technologies that help to comply with increasing regulatory and capacity requirements of the entire biopharmaceutical manufacturing industry, including vaccines.

Improvements in Downstream Recovery Enhance Ultimate Process Yield for Drug Products

The downstream processing market is expected to cross US$ 25.4 Bn by the end of 2030 at a CAGR of ~13%. However, there is a need to remove bottlenecks associated with downstream production whilst achieving cost efficiency.

Companies in the downstream processing market are increasing efforts to improve raw materials characterization and use precisely controlled bioreactors to increase upstream yields. However, improvements in downstream throughput are not keeping pace with upstream, resulting in potential bottlenecks in end-to-end processes. Hence, companies are focusing on significant capital investments in order to create larger chromatography systems for managing large production volumes. Improvements in downstream recovery is emerging as a cost efficient way of enhancing ultimate process yield for drug products.

Single-use Systems Help Speed up Product Recovery, Simplify Downstream Operations

Single-use systems are helping to achieve low production quantities, improved target recovery, and increased conformation times. Membrane adsorbers and single-use chromatography columns are being highly publicized in the downstream processing market. This is evident since research laboratories are accustomed to disposable materials, such as pipettes and tubing, and has led to the acceptance of single-use filters, chromatography columns, and membrane adsorbers.

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New technologies such as spin-filters for product concentration or diafiltration are also helping to simplify downstream operations. This explains why the downstream processing market is projected to advance at a rapid pace during the forecast period. Single-use systems are helping to speed up product recovery for initial target design & confirmation and tests in animals.

Foam Fractionation Methods Help Evaluate Separation Efficiency of Biochemical Components

New process concepts and innovations in foam fractionation methods are grabbing the attention of stakeholders in the downstream processing market. For instance, Lehrstuhl für Anlagen- und Prozesstechnik – a university department in Garching bei München, Germany, is gaining recognition for its Tunable Aqueous Polymer Phase Impregnated Resins (TAPPIR) as alternative technique to classical ATPE. CPC is gaining popularity as a new technology for enzymatic reactions combined with simultaneous product separation.

Foam fractionation methods involve the evaluation of separation efficiency for biochemical components from complex fermentation broth. Companies in the downstream processing market are investigating hydrodynamic and adsorption kinetics in foam.

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Advancements in Acoustophoresis Lead to Innovations in Ultrasonic Cell Separation

Innovations in technology and equipment have benefitted downstream processing. Advancements in acoustophoresis i.e. ultrasonic cell separation and high precision microfluidics for label-free cell selection are acting as key drivers for growth in the downstream processing market. Companies are gaining a strong research base in rapid gene delivery and in-line cell washing, which leads to significant productivity gains.

In order to accomplish cell separation on a clinical blood sample, companies in the downstream processing market are partnering with researchers to develop systems that perform acoustophoresis in high performance microfluidic devices. Such systems are bypassing the need for centrifugation. In the gene therapy space, companies are increasing efforts to develop microfluidic transduction modules that can co-localize viral vector around cells.

Analysts’ Viewpoint

Due to mass inoculation of COVID-19 vaccines being supplied from India, companies in the India downstream processing market are under scrutiny for using ligand technologies to purify vaccines. Companies are realizing that the ultimate goal of downstream optimization is to improve recovery and reduce the cost per gram of protein produced. However, the complexity of downstream production is affecting market growth, since finding efficiencies and economies of scale across downstream processing steps involves complex analysis and optimization. Hence, companies should investigate key aspects of current purification steps and technologies involving the use of mixed-mode and multimode chromatography resins. They are exploring ways to make chromatographic buffers more effective by using new kinds of additives.

Downstream Processing Market: Overview

The global downstream processing market was valued over US$ 6.7 Bn in 2019. It is projected to expand at a rapid pace from 2020 to 2030. Downstream processing is a multistep series of operations that are performed after the fermentation process for the recovery and purification of desired products. It comprises removal of insoluble, product isolation, product purification, and product polishing.

The global downstream processing market is driven by rise in incidence rates of chronic disorders with significant unmet medical needs, increase in demand for vaccines for COVID-19, introduction of new products and solutions for microbial fermentation, and development of new biotherapeutics with smaller molecular weight

Downstream Processing Market: Segmentation

The global downstream processing market has been segmented based on technique, product, application, end user, and region

In terms of technique, the global downstream processing market has been categorized into purification, solid-liquid separation, and clarification/concentration

In terms of product, the global downstream processing market has been categorized into basic chromatography columns & resins, filters, membrane absorbers, single-use products, and others

Based on application, the global downstream processing market has been classified into monoclonal antibody production, vaccine production, insulin production, immunoglobulin production, erythropoietin production, and others

Based on end user, the global downstream processing market has been bifurcated into biopharmaceutical manufacturers and contract research organizations

Consistent Expansion of Biopharmaceutical and Biotechnology Industries to Boost Downstream Processing Market

Expansion of the biopharmaceutical industry can be attributed to high efficacy and fewer side effects, which these drugs offer. Similarly, the biotechnology industry has been expanding significantly, owing to continuous evolution in available technologies and introduction of new ones.

Major pharmaceutical companies have been focusing on the biopharma industry over the past few years by investing in biotech R&D, which has resulted in better returns as compared to the average of the pharmaceutical industry in general

Development of New Biotherapeutics with Smaller Molecular Weight to Drive Downstream Processing Market

Development of new biotherapeutics with smaller molecular weight is likely to drive the adoption of upstream as well as downstream processing equipment. Usage of these systems for the production of monoclonal antibodies, recombinant proteins, antibody fragments, antibody drug conjugate (ADCs) components, and small peptide fragments is likely to increase in the near future.

Introduction of personalized medicines and varying product portfolio are likely to propel the demand for more flexible and small-to-medium capacity production. Instead of using large capacity fermenters, biopharmaceutical manufacturers can rely on small-scale, single-use systems with capacity of 100 liters to 500 liters to produce these biotherapeutics.

Thus, development of new biotherapeutics with smaller molecular weight is estimated to boost the global downstream processing market during the forecast period

Limitations & Constraints in Producing Humanized Peptides to Hamper Downstream Processing Market

Microbial fermentation systems offer benefits such as short production time and high yield. However, there are certain limitations that hamper the use of microbial cell systems for biopharmaceutical production.

Numerous microbial cells, especially bacterial cells, synthesize the peptides in inclusion bodies. Extraction of the peptide of interest by cell lysis is a cumbersome process and attracts additional cost and downstream processing.

Bacterial cell systems have limitations in producing high molecular weight peptides and other metabolites, which limits their application in the production of small molecular weight recombinant proteins, antibiotics, and amino acids. However, yeast cells can be employed to produce large molecular weight peptides and metabolites. Thus, these factors are estimated to restrain the global downstream processing market during the forecast period.

Regional Segmentation

In terms of region, the global downstream processing market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa

North America dominated the global downstream processing market in 2019, and the trend is expected to continue during the forecast period

The downstream processing market in Asia Pacific is anticipated to expand at a high CAGR from 2020 to 2030. Expansion of the market in the region can be attributed to the rapid expansion of the biopharmaceutical industry in India and China, and focus of leading players on strengthening presence in emerging markets.

Major Players

Key players operating in the global downstream processing market include

  • Danaher Corporation
  • Merck KGaA
  • Sartoris Stedim Biotech S.A.
  • Thermo Fisher Scientific Inc.
  • 3M Company
  • Lonza Group
  • Eppendorf AG

Boehringer Ingelheim International GmbH

These players focus on enhancing their production capabilities to cater to the rising demand for downstream processing equipment, owing to the growing pandemic of coronavirus. Furthermore, a key trend of strategic mergers and acquisitions has been witnessed among leading players to strengthen their competitive position in the global market.

In March 2020, Danaher Corporation completed the acquisition of the Biopharma business from General Electric Company’s Life Sciences division. The acquisition enabled the company to strengthen its life sciences segment.

In March 2020, Eppendorf AG acquired Koki Holdings Co., Ltd. This acquisition enabled the company to enhance the centrifuge business and consolidate its market position.

Key Questions Answered in Downstream Processing Market Report

  • What will be the sales revenue generated by downstream processing across all regions during the forecast period?
  • What are the key trends in the global downstream processing market?
  • What are major drivers, restraints, and opportunities in the global downstream processing market?
  • Which regional market is set to expand at the fastest CAGR during the forecast period?
  • Which application segment will generate the maximum revenue by 2030 and which product segment will expand at the fastest CAGR during the forecast period?

Downstream Processing Market – Segmentation

Technique

  • Purification
  • Solid-Liquid Separation
  • Clarification/Concentration

Product

  • Chromatography Columns & Resins
  • Filters
  • Membrane Absorbers
  • Single-use Products
  • Others

Application

  • Monoclonal Antibody Production
  • Vaccine Production
  • Insulin Production
  • Immunoglobulin Production
  • Erythropoietin Production
  • Others

End User

  • Biopharmaceutical Manufacturers
  • Contract Manufacturing Organizations

Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

TABLE OF CONTENT

1. Preface

1.1. Market Definition and Scope

1.2. Market Segmentation

1.3. Key Research Objectives

1.4. Research Highlights

2. Assumptions and Research Methodology

3. Executive Summary: Global Downstream Processing Market

4. Market Overview

4.1. Definition

4.2. Market Indicators

4.3. Market Dynamics

4.3.1. Drivers

4.3.2. Restraints

4.3.3. Opportunities

4.4. Global Downstream Processing Market Value (US$ Mn) Forecast, 2018–2030

4.5. Global Downstream Processing Market Outlook

5. Key Insights

5.1. COVID-19 Pandemic Impact on Industry (value chain and short / mid / long term impact)

5.2. Key Industry Events (Merger, Acquisitions, Collaborations, Approvals, etc.) List of Key Manufacturers & Distributors, by Each Region

6. Global Downstream Processing Market Analysis and Forecast, by Technique

6.1. Introduction

6.2. Global Downstream Processing Market Value Share Analysis, by Technique

6.3. Global Downstream Processing Market Value Forecast, by Technique, 2018–2030

6.3.1. Purification

6.3.2. Solid-liquid Separation

6.3.3. Clarification/Concentration

6.4. Global Downstream Processing Market Attractiveness Analysis, by Technique

7. Global Downstream Processing Market Analysis and Forecast, by Product

7.1. Introduction

7.2. Global Downstream Processing Market Value Share Analysis, by Product

7.3. Global Downstream Processing Market Value Forecast, by Product, 2018–2030

7.3.1. Chromatography Columns & Resins

7.3.2. Filters

7.3.3. Membrane Absorbers

7.3.4. Single-use Products

7.3.5. Others

8. Global Downstream Processing Market Analysis and Forecast, by Application

8.1. Introduction

8.2. Global Downstream Processing Market Value Share Analysis, by Application

8.3. Global Downstream Processing Market Value Forecast, by Application, 2018–2030

8.3.1. Monoclonal Antibody Production

8.3.2. Vaccine Production

8.3.3. Insulin Production

8.3.4. Immunoglobulin Production

8.3.5. Erythropoietin Production

8.3.6. Others

8.4. Global Downstream Processing Market Attractiveness Analysis, by Application

9. Global Downstream Processing Market Analysis and Forecast, by End-user

9.1. Introduction

9.2. Global Downstream Processing Market Value Share Analysis, by End-user

9.3. Global Downstream Processing Market Value Forecast, by End-user, 2018–2030

9.3.1. Biopharmaceutical Manufacturers

9.3.2. Contract Manufacturing Organizations

9.4. Global Downstream Processing Market Attractiveness Analysis, by End-user

10. Global Downstream Processing Market Analysis and Forecast, by Region

10.1. Regional Outlook

10.2. Introduction

10.3. Global Downstream Processing Market Value Forecast, by Region

10.3.1. North America

10.3.2. Europe

10.3.3. Asia Pacific

10.3.4. Latin America

10.3.5. Middle East & Africa

10.4.  Global Downstream Processing Market Attractiveness Analysis, by Region

11. North America Downstream Processing Market Analysis and Forecast

11.1.  Key Findings

11.2.  North America Downstream Processing Market Value Forecast, by Technique, 2018–2030

11.2.1. Purification

11.2.2. Solid-liquid Separation

11.2.3. Clarification/Concentration

11.3. North America Downstream Processing Market Value Forecast, by Product, 2018–2030

11.3.1. Chromatography Columns & Resins

11.3.2. Filters

11.3.3. Membrane Absorbers

11.3.4. Single-use Products

11.3.5. Others

11.4. North America Downstream Processing Market Value Forecast, by Application, 2018-2030

11.4.1. Monoclonal Antibody Production

11.4.2. Vaccine Production

11.4.3. Insulin Production

11.4.4. Immunoglobulin Production

11.4.5. Erythropoietin Production

11.4.6. Others

11.5. North America Downstream Processing Market Value Forecast, by End-user, 2018–2030

11.5.1. Biopharmaceutical Manufacturers

11.5.2. Contract Manufacturing Organizations

11.6. North America Downstream Processing Market Value Forecast, by Country, 2018–2030

11.6.1. U.S.

11.6.2. Canada

11.7. North America Downstream Processing Market Attractiveness Analysis

11.7.1. By Technique

11.7.2. By Product

11.7.3. By Application

11.7.4. By End-user

11.7.5. By Country

12. Europe Downstream Processing Market Analysis and Forecast

12.1.  Key Findings

12.2.  Europe Downstream Processing Market Value Forecast, by Technique, 2018–2030

12.2.1. Purification

12.2.2. Solid-liquid Separation

12.2.3. Clarification/Concentration

12.3. Europe Downstream Processing Market Value Forecast, by Product, 2018–2030

12.3.1. Chromatography Columns & Resins

12.3.2. Filters

12.3.3. Membrane Absorbers

12.3.4. Single-use Products

12.3.5. Others

12.4. Europe Downstream Processing Market Value Forecast, by Application, 2018-2030

12.4.1. Monoclonal Antibody Production

12.4.2. Vaccine Production

12.4.3. Insulin Production

12.4.4. Immunoglobulin Production

12.4.5. Erythropoietin Production

12.4.6. Others

12.5. Europe Downstream Processing Market Value Forecast, by End-user, 2018–2030

12.5.1. Biopharmaceutical Manufacturers

12.5.2. Contract Manufacturing Organizations

12.6. Europe Downstream Processing Market Value Forecast, by Country/Sub-region, 2018–2030

12.6.1. U.K.

12.6.2. Germany

12.6.3. France

12.6.4. Italy

12.6.5. Spain

12.6.6. Rest of Europe

12.7. Europe Downstream Processing Market Attractiveness Analysis

12.7.1. By Technique

12.7.2. By Product

12.7.3. By Application

12.7.4. By End-user

12.7.5. By Country/Sub-region

13. Asia Pacific Downstream Processing Market Analysis and Forecast

13.1.  Key Findings

13.2. Asia Pacific Downstream Processing Market Value Forecast, by Technique, 2018–2030

13.2.1. Purification

13.2.2. Solid-liquid Separation

13.2.3. Clarification/Concentration

13.3. Asia Pacific Downstream Processing Market Value Forecast, by Product, 2018–2030

13.3.1. Chromatography Columns & Resins

13.3.2. Filters

13.3.3. Membrane Absorbers

13.3.4. Single-use Products

13.3.5. Others

13.4. Asia Pacific Downstream Processing Market Value Forecast, by Application, 2018-2030

13.4.1. Monoclonal Antibody Production

13.4.2. Vaccine Production

13.4.3. Insulin Production

13.4.4. Immunoglobulin Production

13.4.5. Erythropoietin Production

13.4.6. Others

13.5. Asia Pacific Downstream Processing Market Value Forecast, by End-user, 2018–2030

13.5.1. Biopharmaceutical Manufacturers

13.5.2. Contract Manufacturing Organizations

13.6. Asia Pacific Downstream Processing Market Value Forecast, by Country/Sub-region, 2018–2030

13.6.1. China

13.6.2. India

13.6.3. Japan

13.6.4. Australia & New Zealand

13.6.5. Rest of Asia Pacific

13.7. Asia Pacific Downstream Processing Market Attractiveness Analysis

13.7.1. By Technique

13.7.2. By Product

13.7.3. By Application

13.7.4. By End-user

13.7.5. By Country/Sub-region

14. Latin America Downstream Processing Market Analysis and Forecast

14.1.  Key Findings

14.2. Latin America Downstream Processing Market Value Forecast, by Technique, 2018–2030

14.2.1. Purification

14.2.2. Solid-liquid Separation

14.2.3. Clarification/Concentration

14.3.  Latin America Downstream Processing Market Value Forecast, by Product, 2018–2030

14.3.1. Chromatography Columns & Resins

14.3.2. Filters

14.3.3. Membrane Absorbers

14.3.4. Single-use Products

14.3.5. Others

14.4. Latin America Downstream Processing Market Value Forecast, by Application, 2018-2030

14.4.1. Monoclonal Antibody Production

14.4.2. Vaccine Production

14.4.3. Insulin Production

14.4.4. Immunoglobulin Production

14.4.5. Erythropoietin Production

14.4.6. Others

14.5. Latin America Downstream Processing Market Value Forecast, by End-user, 2018–2030

14.5.1. Biopharmaceutical Manufacturers

14.5.2. Contract Manufacturing Organizations

14.6. Latin America Downstream Processing Market Value Forecast, by Country/Sub-region, 2018–2030

14.6.1. Brazil

14.6.2. Mexico

14.6.3. Rest of Latin America

14.7. Latin America Downstream Processing Market Attractiveness Analysis

14.7.1. By Technique

14.7.2. By Product

14.7.3. By Application

14.7.4. By End-user

14.7.5. By Country/Sub-region

15. Middle East & Africa Downstream Processing Market Analysis and Forecast

15.1.  Key Findings

15.2. Middle East & Africa Downstream Processing Market Value Forecast, by Technique, 2018–2030

15.2.1. Purification

15.2.2. Solid-liquid Separation

15.2.3. Clarification/Concentration

15.3. Middle East & Africa Downstream Processing Market Value Forecast, by Product, 2018–2030

15.3.1. Chromatography Columns & Resins

15.3.2. Filters

15.3.3. Membrane Absorbers

15.3.4. Single-use Products

15.3.5. Others

15.4. Middle East & Africa Downstream Processing Market Value Forecast, by Application, 2018-2030

15.4.1. Monoclonal Antibody Production

15.4.2. Vaccine Production

15.4.3. Insulin Production

15.4.4. Immunoglobulin Production

15.4.5. Erythropoietin Production

15.4.6. Others

15.5. Middle East & Africa Downstream Processing Market Value Forecast, by End-user, 2018–2030

15.5.1. Biopharmaceutical Manufacturers

15.5.2. Contract Manufacturing Organizations

15.6. Middle East & Africa Downstream Processing Market Value Forecast, by Country/Sub-region, 2018–2030

15.6.1. GCC Countries

15.6.2. South Africa

15.6.3. Rest of Middle East & Africa

15.7. Middle East & Africa Downstream Processing Market Attractiveness Analysis

15.7.1. By Technique

15.7.2. By Product

15.7.3. By Application

15.7.4. By End-user

15.7.5. By Country/Sub-region

16. Competition Landscape

16.1.  Market Player – Competition Matrix (by tier and size of companies)

16.2.  Market Share Analysis, by Company, 2020

16.3. Company Profiles

16.3.1. Thermo Fisher Scientific, Inc.

16.3.1.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.1.2. Financial Overview

16.3.1.3. Product Portfolio

16.3.1.4. Strategic Overview

16.3.1.5. SWOT Analysis

16.3.2. 3M Company

16.3.2.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.2.2. Financial Overview

16.3.2.3. Product Portfolio

16.3.2.4. Strategic Overview

16.3.2.5. SWOT Analysis

16.3.3. Danaher Corporation

16.3.3.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.3.2. Financial Overview

16.3.3.3. Product Portfolio

16.3.3.4. Strategic Overview

16.3.3.5. SWOT Analysis

16.3.4. Merck KGaA

16.3.4.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.4.2. Financial Overview

16.3.4.3. Product Portfolio

16.3.4.4. Strategic Overview

16.3.4.5. SWOT Analysis

16.3.5. Lonza Group

16.3.5.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.5.2. Financial Overview

16.3.5.3. Product Portfolio

16.3.5.4. Strategic Overview

16.3.5.5. SWOT Analysis

16.3.6. Eppendorf AG

16.3.6.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.6.2. Financial Overview

16.3.6.3. Product Portfolio

16.3.6.4. Strategic Overview

16.3.6.5. SWOT Analysis

16.3.7. Sartorius AG

16.3.7.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.7.2. Financial Overview

16.3.7.3. Product Portfolio

16.3.7.4. Strategic Overview

16.3.7.5. SWOT Analysis

16.3.8. Boehringer Ingelheim International GmbH

16.3.8.1. Company Overview (HQ, Business Segments, Employee Strength)

16.3.8.2. Financial Overview

16.3.8.3. Product Portfolio

16.3.8.4. Strategic Overview

16.3.8.5. SWOT Analysis

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